Job ID355354 LocationTwin Cities Job FamilyAcademic Full/Part TimeFull-Time Regular/TemporaryRegular Job Code9546 Employee ClassAcad Prof and Admin About the Job Postdoctoral Associates in Neurodegenerative Diseases Multiple NIH-grant funded openings are available for postdoctoral scientists to study the pathogenic mechanisms of Alzheimer's disease (AD) First project aims to define the role of BACH-1 in the AD (RF1AG077396). BACH1 is transcriptional factor that represses Nrf2, a transcriptional factor that induces multiple neuroprotective pathways. We found that pharmacological and genetic repression of BACH1 attenuates AD-related neuropathology and neurodegeneration in transgenic mouse model of AD. We are currently defining how inhibition of BACH1 leads to neuroprotection in AD models. Second project, working in collaboration with Dr. Michael Farrar (Center for Immunology, UofM), aims to study the role of regulatory T (Treg) cells in AD (R01AG078731). While CNS inflammation, particularly microglial activation, is a key component of AD pathogenesis, peripheral adoptive immunity, largely mediated by T-cells, is emerging as a significant pathologic component in AD. Among the T cells, Tregs functions to attenuate too much inflammatory activation via suppression of effector T-cells and microglia. Initial human studies indicate to reduced Treg function in AD and in mouse models of AD. In this project, we will characterize molecular features of Treg and effector T cells in AD and whether distinct subsets of Tregs can modulate AD pathology in vivo. The projects will utilize mouse genetics, immunological/cell biological/biochemical approaches, genomic analysis (RNAseq, snRNAseq, Spatial transcriptomics), high-content immunohistochemical analysis, quantitative neuropathology, and behavioral analysis. The laboratory is funded by multiple grants from Federal/Private sources and involve extensive national/international collaborations with a diverse group of investigators. The laboratory is located within the Wallin Medical Biosciences Building at University of Minnesota, housing the Center for Neurodegenerative Diseases, Institute for Translational Neuroscience, and Center for Immunology. Candidate will join a highly collaborative, vibrant, and supportive laboratory environment currently consisting of multiple postdoctoral fellows, students and supporting staff. Candidates must have a Ph.D. and/or M.D. degree with strong background in relevant Biomedical Sciences. Fluency in English is also essential. We will prioritize individuals who have background or interest in the following approaches: quantitative analysis of neuropathology and neurodegeneration, neuroimmunology, studies of protein quality control, and/or single cell/spatial transcriptomics. Benefits Working at the University At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work. The University also offers a comprehensive benefits package that includes: Competitive wages, paid holidays, and generous time off Continuous learning opportunities through professional training and degree-seeking programs supported by the Low-cost medical, dental, and pharmacy plans Healthcare and dependent care flexible spending accounts University HSA contributions Disability and employer-paid life insurance Employee wellbeing program Excellent retirement plans with employer contribution Public Service Loan Forgiveness (PSLF) Financial counseling services Employee Assistance Program with eight sessions of counseling at no cost Please visit the for more information regarding benefits. How To Apply Appointment level and salary will be commensurate with the relevant experience. Candidates should email C.V. brief statement of prior research and future goals (1-2 pages), and contact information for at least referees to Michael K. Lee, Ph.D. (mklee@umn.edu). Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will have the opportunity to complete an online application for the position and attach a cover letter and resume. Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section. This position will remain open until filled. To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647). Diversity The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: Employment Requirements Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment. About the U of M The University of Minnesota, Twin Cities (UMTC) The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations. The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.